Celebrating the discovery of mutated CALR

MPN Research Foundation is proud to celebrate the 10-year anniversary of the identification of CALR as a common driver of MPNs. We funded early work that discovered this MPN driver mutation. Learn more >
MPNRF by the numbers
Total donated dollars
invested in research
$ 0 M
Researchers supported
0
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supported research
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Projects funded
0

What is
essential
thrombocythemia
(ET)
?

Essential Thrombocythemia (ET)

Most commonly diagnosed in women over the age of 50, ET is associated with a proliferation of platelet precursors in the bone marrow and complications frequently include blood clotting and/or bleeding.

Learn more about ET

What is
polycythemia vera
(PV)
?

Polycythemia
vera (PV)

The disease is most common in men over the age of 60, but anyone can develop PV. PV patients typically experience an elevated red blood cell count, an elevated platelet count and an enlarged spleen, especially over time.

Learn more about PV

Myelofibrosis (MF)

MF is a chronic blood cancer in which excessive scar tissue forms in the bone marrow and impairs its ability to produce normal blood cells.

Learn more about MF

What is
myelofibrosis
(MF)
?

Patients, clinicians, researchers, and the biotech and pharma industries all have critical roles to play in advancing MPN research and are all important members of the MPNRF community.
Connect with us to be part of our coordinated effort to find new treatments — and eventually cures — for MPNs.

Patients
and Caregivers

Every patient experience is unique and provides new clues for researchers and clinicians.

Researchers
and
Clinicians

In our 24-year history, MPNRF has contributed to some of the most influential MPN research discoveries.

Industry
and
Biopharma

Engage with us to ensure that new therapies have the maximum impact on patient outcomes and quality of life.

Download our Voice of the Patient report

Ready to do more?

Julie and her family joined team MPN and created HikeMF to join the fight against MPNs.

Stay connected

Invest in MPN research

Your investment supports doctors and researchers around the world who are dedicated to finding cures for MPNs.

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Recent news

  • NCCN updates guidance on interferon in essential thrombocythemia

    MPN NEWS | March 30, 2026

    “A category 1 designation from the NCCN is not just a footnote change — it’s a signal flare,” said Dr. Aaron Gerds, MD, a hematologist, clinical investigator in MPNs, and Chair of the NCCN Myeloproliferative Neoplasms Panel. “It tells clinicians, patients, and payers that the data have matured to the point where this is no… Read More »NCCN updates guidance on interferon in essential thrombocythemia

    READ MORE

    Research spotlight: Dr. Linda Resar

    MPN NEWS | March 30, 2026

    In the clinic with a young MPN patient  A young adult sits across from Dr. Linda Resar, hands clasped, voice unsteady. The diagnosis is a mouthful — a myeloproliferative neoplasm (MPN) — and feels impossible. As Resar explains, “They go to the internet and they say, ‘Wow, I have cancer! I’m so young! This has to be devastating.’”   She slows the… Read More »Research spotlight: Dr. Linda Resar

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    The power of persistence: MPN researchers honored with Ernest Beutler Prize at ASH 2025 

    MPN NEWS | January 27, 2026

    Inside the Orlando Convention Center, a room as vast as an airline hangar was bathed in green light from numerous two-story-high screens. Thousands of hematology researchers filled the space, waiting for a marquee lecture.  This was the Ernest Beutler Lecture and Prize session at the American Society of Hematology’s (ASH) 2025 annual meeting — one of hematology’s… Read More »The power of persistence: MPN researchers honored with Ernest Beutler Prize at ASH 2025 

    READ MORE