MPNRF goes after the JAK2 mutation and the mysteries of Interferon with new project

September 15, 2017

Interferon (IFN) is a drug that has proven to be effective in other diseases (e.g., hepatitis C), but has largely been replaced by a new generation drugs for those diseases. However, it remains the single treatment that provides disease-altering effects for MPN patients, and understanding its mechanism of action for MPNs can lead to better interferon compounds and potentially other drugs in the IFN pathway that can change the prognosis for MPN and other cancer patients.

The MPNRF Interferon (IFN) Initiative is a multi-center project which will bring together internationally recognized experts in both blood and solid tumors to determine how cytokine-driven pathways affect the trajectory of the MPNs, a closely-related group of progressive blood cancers.  The collaboration among this group of scientists is unprecedented and speaks to their drive to answer this question, which could have wide-ranging impact on the lives of people living with cancer. Specifically, the project is aimed at defining:

  • How and why targeting the IFN pathway reduces the burden of mutated stem cells in MPN patients.
  • Why targeting this pathway is effective for some MPN patients but not others.
  • Why the positive effects of targeting this pathway are not permanent.

This initiative will be funded by MPN patients and supporters, and by generous unrestricted contributions from PharmaEssentia and Incyte.

Barbara Van Husen, President of MPNRF, says “We have long felt that a study of Interferon would be a unique opportunity to open new avenues of treatment for MPN patients. We held an Interferon Brainstorming Session in 2016 at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, and became convinced we should spearhead this effort.”

 “Working together and sharing knowledge is key,” says Leonidas Platanias, MD, PhD, Director of the Lurie Cancer Center, Jesse, Sara, Andrew, Abigail, Benjamin and Elizabeth Lurie Professor of Oncology and lead investigator of the multicenter effort. “As our understanding of complex cytokine pathways and signaling networks continues to evolve, we expect to maximize the impact of these discoveries by developing new therapies for patients with MPN.”

The MPNRF IFN Initiative will bring world experts in Interferon, MPNs, and solid tumors together to bring both broad and deep understanding to this issue.  The initial team of investigators includes:

Leonidas Platanias, MD, PhD: Lurie Cancer Center
Ann Mullally, MD: Division of Hematology, Brigham and Woman’s Hospital
Jean-Luc Villeval, PhD: INSERM/Institut Gustave Roussy, Paris
Joseph Scandura, MD, PhD: Weill Cornell School  of Medicine

The project will be guided by an Advisory Group of recognized experts in Interferon and MPNs that will meet with investigators to ensure that the collaboration is optimal and productive.  Members of the Advisory Group include:  Andrew Schafer, MD (chair); John Crispino, PhD; Robert Cohen, MD; Ronald Hoffman, MD; Richard Silver, MD; Jean-Jacques Kiladjian, MD, PhD; William Vainchenker, MD, PhD; Radek Skoda, MD and Hans Hasselbalch, MD.

It is MPNRF’s hope and determination that this project will bring discoveries to light for MPN patients, and will provide an essential weapon in the arsenal of treatments available to them and to patients with other cancers.

About The Myeloproliferative Research Foundation

The MPN Research Foundation is the only organization fully dedicated to funding research into the myeloproliferative neoplasms, a rare group of blood cancers which include polycythemia vera, essential thrombocythemia and myelofibrosis. Founded in 2000 by a group of patients, the focus is to fund high innovation research that can expand our understanding of the MPNs and get us closer to a cure.

The Foundation’s Scientific Advisory Board works with the patient-led board of directors to utilize a rigorous selection process to ensure donations are allocated to the most innovative research projects. To date, the Foundation has awarded twelve million dollars for MPN research. More information may be obtained at www.mpnrf.org or by contacting us at mwoehrle@mpnrf.org or 312-683-7243.
 

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