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The many paths of MPNs: New research explores the various genetic paths of patients
Myeloproliferative neoplasms (MPNs) are rare blood cancers that often unfold slowly. Some people live with stable disease for many years, while others experience progression to myelofibrosis or acute myeloid leukemia (AML). Understanding why these paths differ is a central challenge in MPN research.
A new study, Genomic evolution and natural history of myeloproliferative neoplasms on therapy, led by researchers including Dr. Jyoti Nangalia, takes a long view of this question (Leongamornlert et al., 2026). The project tracks how the genetic makeup of MPN patients change over time and across diagnoses.
EHA & ASCO clinical trial read outs: How these impact patient quality of life
The thrill that drives researchers: Dr. Josef Prchal on ambition, competition, and the [selfish] joy of discovery
he road to scientific discovery is littered with disappointment. For researchers like Dr. Josef Prchal, MD, the moments that make the journey worthwhile are not a guaranteed outcome or incremental progress; it is the rare, intoxicating thrill of finding something no one has seen before.