2015-17 funded research

2015-2017 Research Projects

CRISPR Projects

"Establishment of isogenic human induced pluripotent stem cell (hiPSC) lines containing CRISPR engineered MPN mutations" 
George Church, PhD,  Harvard Medical School
   "Precise Genome Editing for Targeting Malignant Clones in MPNs"
   Zhaohui Ye, PhD , Johns Hopkins

   "Correction of JAK2 mutation in myeloproliferative neoplasms by gene editing" 
   Zhijian Qian, PhD and Wen-Shu Wu, PhD, University of Illinois at Chicago

Immunotherapy Projects

"Defining the immunomodulatory properties of mutated calreticulin in MPN" 
Camelia Iancu-Rubin, PhD and Nina Bhardwaj, MD, PhD 
Icahn School of Medicine at Mount Sinai
   "Anti-PDL1 therapy for patients with Myelofibrosis" Learn more!
   Brady Stein, MD Northwestern Feinberg School of Medicine
   "Immunologic Targeting of Calreticulin Gene Mutations in MPN" 
   Robert Kralovoics, CeMM Research Center for Molecular Medicine of the Austrian  Academy of Sciences


Inflammation & the Bone Marrow Niche

"Impact of the inflamed bone marrow niche on the progression of Myeloproliferative Neoplasia and marrow fibrosis"
Nadia Carlesso, MD, PhD, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine 
Improvement in Utilizing Non-Invasive Techniques to Measure Bone Marrow

   "Nanoplatforms for Imaging Bone Marrow Fibrosis” 
   Katya Ravid, MD, PhD, Boston University School of Medicine


Genomic Research into MPN

“Identifying factors that promote clonal dominance in zebrafish hematopoiesis for the treatment of myeloproliferative neoplasms” Learn more about recent breakthroughs from Dr. Zon's lab
Leonard Zon, MD, Boston Children's Hospital

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