2014 MPN Challenge Robert Kralovics

Robert Kralovics, CEMM

Project Title:

Immunologic Targeting of Calreticulin Gene Mutations in MPN

Focus Area(s):

CALR Mutation; Immunotherapy

Brief Description:

This project should be of interest for those patients who have the CALR mutation (ET and MF patients). Because the CALR is found close to the surface of the myeloid cell, it may be easier to target. This project is hoping to target a specific amino acid where the CALR mutation is located with antibodies or develop a vaccine from that amino acid to use as an immunization.