2014 MPN Challenge: Villeval; Pellegrini; Constantinescu

INSERM/Institut Gustave Roussy, University Paris XI, France; Institut Pasteur Paris, France; de Duve Institute, Université catholique de Louvain, Brussels, Belgium; Ludwig Cancer Research Institute, Brussels, Belgium

Jean Luc Villeval MPN ResearcherProject Title:

Mechanisms of Sensibility and Resistance of MPN Hematopoietic Stem Cells to IFNα Therapy

Focus Area(s):

CALR Mutation; Reducing the MPN Allele Burden; Selective JAK2

Brief Description:

The primary goal of this multi-center and multi-investigator project is to elucidate how Pegasys targets the JAK2 mutation. They will also seek to determine if Pegasys also targets CALR positive hematopoetic stem cells, and to understand why some patients are resistant to Pegasys.

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