Research Funded
MPN Research Foundation Grant Recipients
Since 2000, the MPN Research Foundation (formerly MPD Foundation) has awarded grants to worthy MPN researchers on a quest to advance the science of MPNs in the field of drug development, epidemiology and general research.
The primary mission of the MPN Research Foundation is to stimulate original research in pursuit of new treatments -- and eventually a cure -- for myeloproliferative neoplasms (MPNs). To date, the Foundation has awarded over $8 million for MPN research, including these grants.
Click here for types of research we fund and how to apply for a grant.
Click here for a list of selected abstracts from MPN Research Foundation funded grants.
2011 - 2013
Ruben Mesa, MD
Mayo Clinic, Scottsdale
"Validation of use of the Myeloproliferative Neoplasm Symptom Assessment Form Diary to Assess Symptomatic Pains in Patients with Polycythemia Vera and Post Polycythemia Vera"
Established Investigators:
Robert I. Handin, MD
Brigham and Women's Hospital, Harvard Medical School
"HDAC Inhibitors and Red Cell Proliferation in Zebrafish Embryos Expressing Human JAK2V617F"
Shaoguang Li, MD PhD
University of Massachusetts Medical School
"Identification of Alox5 as a Potential Target Gene for the Treatment of Polycythemia Vera"
Robert Kralovics, PhD
Austrian Academy of Sciences, Vienna
"Deciphering the Genetic Complexity of Myeloproliferative Disorders"
Benjamin Ebert, MD PhD and Ross Levine, MD
Harvard Medical School and Memorial Sloan Kettering, respectively
"Whole Genome Sequencing to Identify Germline and Somatic Disease Alleles Which Contribute to MPD Pathogenesis"
New Investigators:
Toshiaki Kawakami, MD PhD
La Jolla Institute for Allergy and Immunology
"SPS Complex in MPD"
Wei Tong, PhD
Children's Hospital of Pennsylvania
"K63 Ubiquitination in JAK2 Signaling and Myeloproliferative Neoplasms"
Saghi Ghaffari, MD PhD
Mt. Sinai School of Medicine
"Understanding Molecular Mechanisms of Regulation of Myeloproliferative Disorders in Mouse and Human"
2009-2010
MPD Research Alliance:
Gary Gilliland, MD, PhD
Harvard Medical School
"Genetics and Therapy of Myeloproliferative Disorders"
Ronald Hoffman, MD
Mt. Sinai School of Medicine
"Use of Stem Cells Derived from the Philadelphia Chromosome Negative Myeloproliferative Disorders as a Chemotherapeutic Target"
Josef Prchal, MD
University of Utah
Define somatic mutations that precede JAK2 mutation in PV patients & monitor their changes in response to Pegasys"
Ayalew Tefferi, MD
Mayo Clinic
"Continued Development of Clinical Database-Linked Cell and Serum Bank of Patients with Myeloproliferative Disorders"
New Investigator:
Benjamin Braun, MD, PhD
University of California, San Francisco
"Oncogenic Ras in Leukemia Stem Cells"
Francois Delhommeau, PhD, PharmD
Saint-Antoine Hospital, Paris
"Characterization and Function of a New Tumor Suppressor Gene in Myeloproliferative Disorders"
Robert Kralovics, PhD
Austrian Academy of Sciences, Vienna
"Genomic approaches for disease gene identification in myeloproliferative neoplasms"
Dorothy Sipkins, MD, PhD
University of Chicago
"In Vivo Imaging of PV and CIMF CD34+ Progenitor Cell Interactions with Bone Marrow Microenvironment"
2006-2008
Gary Gilliland, PhD, MD
Harvard Medical School
MPD Research Alliance
Ayalew Tefferi, MD
Mayo Clinic, Rochester
MPD Research Alliance
Ronald Hoffman, PhD
Mt. Sinai School of Medicine (2007-Present)
University of Illinois, Chicago (2006-2007)
MPD Research Alliance
Gail Roboz, MD
Weill Cornell Medical College
"Arsenic trioxide (ATO) combined with cytosine arabinoside (ara-c) for the treatment of advanced myelofibrosis and myelofibrosis transformed to acute myeloid leukemia"
2005
Xiaomei Ma, PhD
Yale University School of Medicine
"Epidemiology of Chronic Myeloproliferative Disorders Grant"
2004
Alison Moliterno, MD
Johns Hopkins
"Proteomic Approach to the Diagnosis of Chronic MPD's.
Mingjiang Xu, MD, Ph.D.
University of Illinois, at Chicago
"Exploration of a unique phosphatase as a potential therapeutic target for treatment of PV"
Ron Hoffman, MD
University of Illinois at Chicago
"Continuation of 2003 grant. "
Jose Lopez, MD
Baylor College of Medicine
"Macrophage-derived Prothrombotic Microparticles and Thrombosis in Myeloproliferative Disorders"
2003
Xiao-Feng Yang, MD, PhD
Baylor College of Medicine
"Novel Antigen targets for Immunotherapy in the Myeloproliferative Diseases"
Ruben Mesa, MD
Mayo Clinic, Rochester, NY
"Novel therapies for Myelofibrosis with Myeloid Metaplasia"
Richard D'Andrea, MD
Child Health Research Institute, Australia
"Identification of Growth Factor Receptor Mutations in Polycythemia Vera"
Ron Hoffman, MD
University of Illinois at Chicago
"Organizational grant for International MPD Research Consortium in application for $25 million grant from NCI"
Vahid Afshar-Kharghan, MD
Baylor College of Medicine
"Continuation of 2002 Grant"
2002
Vahid Afshar-Kharghan
MD Baylor College of Medicine
"Genetic factors that influence platelet function in PV and ET, and their effect on the frequency of thrombotic complications."
Dr. Josef Prchal
Baylor College of Medicine
"Continuation of 2001 Grant"
Dr. Josef Prchal
Baylor College of Medicine
"Continuation of 2000 Grant"
2001
Dr. Josef Prchal
Baylor College of Medicine
"Locate and identify the gene or genes whose defects are responsible for ET."
Dr. Josef Prchal
Baylor College of Medicine
"Continuation of 2000 Grant"
2000
Dr. Josef Prchal
Baylor College of Medicine
"Locate and identify the gene or genes that lead to the development of the Polycythemia Vera phenotype."
