Nature Medicine: Drug Stops Reproduction of Cancer Cells in Myelofibrosis

According to a paper published in Nature Medicine, the drug MLN8237 (or Alisertib) has reduced tumor cells, blood counts and fibrosis in mouse models of myelofibrosis. Reports John Crispino, PhD, "This new paper shows that Alisertib has an anti-tumor effect in samples of myelofibrosis, similar to what we saw in megakaryocytic leukemia." 
John Crispino is also the Scientific Advisor for the MPN Research Foundation.

Click here to read the original article from Nature, or the press release from Northwestern quoting both Dr. Crispino and Brady Stein.

There is a clinical trial for Alisertib in people with myelofibrosis currently enrolling at Northwestern. Please visit the clinicaltrials.gov listing for this study for further information including how to enroll.

Author: Woehrle, Michelle

Michelle Woehrle joined the MPN Research Foundation in 2007 after being inspired by their mission to fund research that will improve the lives of people living with the rare blood cancers PV, ET and MF. In 2015 she was promoted to Executive Director. She has assisted with the expansion of the grants program, grassroots initiatives to connect with more patients internationally and optimize operations for the Foundation.

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