2014 MPN Challenge: Leonard Zon
Leonard Zon, Boston Children’s Hospital
Identifying factors that promote clonal dominance in zebrafish hematopoiesis for the treatment of myeloproliferative neoplasms.
Fibrosis and the Bone Marrow Niche; CALR Mutation; Reducing the MPN Allele Burden
They will use unique combinations of fluorescent proteins in zebrafish to help ID changes in the blood before an MPN develops. This could lead to a treatment that would suppress the development of fibrosis earlier.