2014 MPN Challenge: Leonard Zon

Leonard Zon, Boston Children’s Hospital

Project Title:

Identifying factors that promote clonal dominance in zebrafish hematopoiesis for the treatment of myeloproliferative neoplasms.

Focus Area(s): 

Fibrosis and the Bone Marrow Niche; CALR Mutation; Reducing the MPN Allele Burden 

Brief Description: 

They will use unique combinations of fluorescent proteins in zebrafish to help ID changes in the blood before an MPN develops. This could lead to a treatment that would suppress the development of fibrosis earlier.