2014 MPN Challenge Nadia Carlesso & H. Scott Boswell

Nadia Carlesso & H. Schott Boswell, Indiana University School of Medicine

Project Title:

Impact of the inflamed bone marrow niche on the progression of Myeloproliferative Neoplasia and marrow fibrosis

Focus Area(s):

Fibrosis & Bone Marrow Niche; Immunotherapy

Brief Description:

We recognize the mutations that target certain genes (Jak2, Tets, Mpl, or Asxl) and causes inflammation. We don't know how inflammation contributes to disease progression. We also don't know the causes that lead to inflammation. This project will investigate these causes and hopefully this will lead to ways to counteract disease progression.