2014 MPN Challenge Gary Reuther

Gary Reuther, Moffitt Cancer Center

Gary Reuther MPN ResearcherProject Title

Using Pharmacological Synthetic Lethality to Treat MPNs

Focus Area(s)

Selective JAK2 Inhibition

Brief Description 

This project proposes to investigate the role of Pim1 in JAK2 positive MPNs, and explore the possibilities of combination JAK2/ Pim1 inhibitors. As we know, JAK2 inhibitors are not selective. They inhibit the body’s ability to create needed blood cells. If successful the new treatment would inhibit the over production of blood cells but allow the body to produce blood cells when needed.

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Loretta Mae

Myelofibrosis (MF)

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