2014 MPN Challenge Ann Mullally
Ann Mullally, The Brigham and Women’s Hospital
Determination of the role of altered epigenetic regulation of megakaryocytes in the pathogenesis of myelofibrosis
Fibrosis and the Bone Marrow Niche;
Following up on her 2012 MF Challenge grant, this project will identify the role of a specific gene, CHD4, in the development of fibrosis in the bone marrow. This could lead to a way to alter the development of fibrosis sooner.