2014 MPN Challenge: Villeval; Pellegrini; Constantinescu
INSERM/Institut Gustave Roussy, University Paris XI, France; Institut Pasteur Paris, France; de Duve Institute, Université catholique de Louvain, Brussels, Belgium; Ludwig Cancer Research Institute, Brussels, Belgium
Mechanisms of Sensibility and Resistance of MPN Hematopoietic Stem Cells to IFNα Therapy
CALR Mutation; Reducing the MPN Allele Burden; Selective JAK2
The primary goal of this multi-center and multi-investigator project is to elucidate how Pegasys targets the JAK2 mutation. They will also seek to determine if Pegasys also targets CALR positive hematopoetic stem cells, and to understand why some patients are resistant to Pegasys.