2014 MPN Challenge: Angela Fleischman with Richard Van Etten
Angela Fleischman with Richard Van Etten, University of California, Irvine
A key role for lymphoid cells in the pathology of myeloproliferative neoplasm
Fibrosis and the Bone Marrow Niche; Reducing the MPN Allele Burden; Immunotherapy
Inflammation plays a key role in the development of MPNs and the lymphoid cells are key inflammatory cells. Because MPN associated mutations are restricted to blood and bone marrow malignancies, very little research has focused on the lymphoid system. This project will ID the specific lymphoid cell responsible for inflammation. It has been shown that mice lacking certain lymphoid cells do not develop an MPN despite the presence of JAK2V617F cells. They hope to identify the specific lymphoid cell type responsible for the development of an MPN, hopefully leading to a new treatment option.