Celebrating the discovery of mutated CALR
Celebrating the discovery of mutated CALR
What is
essential
thrombocythemia
(ET)?
Most commonly diagnosed in women over the age of 50, ET is associated with a proliferation of platelet precursors in the bone marrow and complications frequently include blood clotting and/or bleeding.
What is
polycythemia vera
(PV)?
The disease is most common in men over the age of 60, but anyone can develop PV. PV patients typically experience an elevated red blood cell count, an elevated platelet count and an enlarged spleen, especially over time.
MF is a chronic blood cancer in which excessive scar tissue forms in the bone marrow and impairs its ability to produce normal blood cells.
What is
myelofibrosis
(MF)?
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MPN Research Foundation: A legacy of impact
MPN NEWS | December 4, 2025
MPN Research Foundation: A legacy of impact Sources Kralovics, R., et al. (2002). Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera. Experimental Hematology, 30(3), 229–236. Klampfl, T., et al. (2013). Somatic mutations of calreticulin in myeloproliferative neoplasms. The New England Journal of Medicine, 369(25), 2379–2390. Moliterno, A. R.,… Read More »MPN Research Foundation: A legacy of impact
Blasts 101 — what they are and where they belong
MPN NEWS | October 29, 2025
Blasts 101 — what they are and where they belong Your body constantly makes new blood cells in the bone marrow, a process called hematopoiesis. Blasts are early, still-developing cells that are in a transitionary stage between stem cells and fully mature blood cells. There are two main types of blast cells that make up… Read More »Blasts 101 — what they are and where they belong
From CALR to the cutting edge: Dr. Ann Mullally’s view of the future of MPN Research
MPN NEWS | October 28, 2025
Few scientists have a clearer view of where myeloproliferative neoplasm (MPN) research is headed than Dr. Ann Mullally, MD. As a physician-scientist, Division Chief of Hematology at Stanford, and member of the MPN Research Foundation’s Scientific Advisory Board (SAB), she sits at the crossroads of patient care, clinical trials, and discovery science. From this vantage… Read More »From CALR to the cutting edge: Dr. Ann Mullally’s view of the future of MPN Research